Pomegranate is one of the healthiest and richest fruit that one may eat. It is rich in vitamin A, C and E and folic acid, which makes it extraordinary for a healthy body and mind.
Health benefits of pomegranates are many. It is interesting to know that even raw pomegranates are nutritious and healthy. There are numerous health benefits of pomegranates. They reduce Heart Disease and disorders. They can also reduce the risk of cancer like Prostate cancer and Breast Cancer. They also help in weight control. Additionally, they are capable of reducing cholesterol and even help in fighting off cell injury.
It is also interesting to know that pomegranates juices are amongst few juices whose both seed and fruit are healthy. The skin or the peel of the pomegranate contains maximum antioxidants, which we cannot eat. These are often released when for juicing the pomegranate is squeezed.
Pomegranate juice again has many benefits when it comes to health and well being. It is not only healthy but tasty as well. It contains material like polyphenols. These polyphenols help in serving as an antioxidant, anti-tumor and anti-viral substance. It also controls cholesterol level in the body and checks triglyceride levels. Also it is a known fact that in osteoarthritis and prostate cancer, pomegranate juice plays a crucial role. Again pomegranate juice is really helpful during pregnancy and ceases the chances of brain injury to the embryo
Sunday, December 13, 2009
Why is Noni Juice so Good For Us?
A Nutritional Supplement Par Excellence
Noni Contains Over 140 Powerful Vitamins, Minerals and Other Nutrients
These vitamins, minerals and other nutrients can affect our bodies in many profound ways. There are also no doubt other vitamins or other substances that have not yet been discovered in Noni, that are nonetheless there in any excellent Noni nutritional supplement, and are also useful.
Noni Juice is a Digestive Tonic*
Noni is a powerful, digestive bitter, rich in natural enzymes. It stimulates the digestive tract and promotes all-around healthy digestion*. This is perhaps one of the reasons that so many users feel positive results despite varied health issues, in addition to the vitamins, minerals and other nutrients found in Noni. Enhanced digestion promotes better health in general, since if we can't digest our foods properly, we can't assimilate the vitamins, minerals and other nutrients that it contains. This may be part of what makes Noni such a powerful natural nutritional supplement.
Noni Contains Anthraquinones
These nutrients in Noni called Anthraquinones help to stimulate the activity of the entire digestive process, increasing much needed secretion, enzymes and bile flow*. Anthraquinones are also effective for pain relief and as a supplement in numerous health conditions*.
Noni contains Proven Anti-Bacterial Agents
These include Acubin, Alizarin, Asperuloside and Anthraqui-none, which fortify and protect against many types of infectious bacteria, including Staphylococcus area, E-coli, Salmonella and Sigel. No wonder many ancient cultures used Noni and Noni Juice as a nutritional supplement to treat fevers, colds, food poisoning skin infections and other bacterial related illnesses.
Noni Contains Over 140 Powerful Vitamins, Minerals and Other Nutrients
These vitamins, minerals and other nutrients can affect our bodies in many profound ways. There are also no doubt other vitamins or other substances that have not yet been discovered in Noni, that are nonetheless there in any excellent Noni nutritional supplement, and are also useful.
Noni Juice is a Digestive Tonic*
Noni is a powerful, digestive bitter, rich in natural enzymes. It stimulates the digestive tract and promotes all-around healthy digestion*. This is perhaps one of the reasons that so many users feel positive results despite varied health issues, in addition to the vitamins, minerals and other nutrients found in Noni. Enhanced digestion promotes better health in general, since if we can't digest our foods properly, we can't assimilate the vitamins, minerals and other nutrients that it contains. This may be part of what makes Noni such a powerful natural nutritional supplement.
Noni Contains Anthraquinones
These nutrients in Noni called Anthraquinones help to stimulate the activity of the entire digestive process, increasing much needed secretion, enzymes and bile flow*. Anthraquinones are also effective for pain relief and as a supplement in numerous health conditions*.
Noni contains Proven Anti-Bacterial Agents
These include Acubin, Alizarin, Asperuloside and Anthraqui-none, which fortify and protect against many types of infectious bacteria, including Staphylococcus area, E-coli, Salmonella and Sigel. No wonder many ancient cultures used Noni and Noni Juice as a nutritional supplement to treat fevers, colds, food poisoning skin infections and other bacterial related illnesses.
What are the Benefits of Pomegranate Juice?
Pomegranate juice represents another of the foods recently touted for its health benefits. In some clinical studies, pomegranate juice has been shown to be of significant benefit, especially in the prevention of heart disease. To start, a glass of pomegranate juice contains about 40% of the US Recommended Daily Allowance (RDA) of Vitamin C. It also has Vitamin A, E and folic acid in good quantities
Further, pomegranate juice has excellent antioxidant properties. It has about three times more antioxidants ounce for ounce than does red wine or green tea. Many people also enjoy its rich taste, making it a welcome beverage.
Pomegranate juice has been shown to work well as a blood thinner. Some research has shown it may be an excellent agent for promoting blood flow to the heart. It also has been shown to reduce plaque in the arteries, and to raise “good” levels of cholesterol while helping lower “bad” cholesterol.
This preliminary research suggests that pomegranate juice may be helpful in preventing heart disease, heart attacks and stroke. Most physicians are quick to point out pomegranate juice should be just one aspect of a healthy diet and exercise program. Pomegranate juice alone would probably not cure or completely prevent heart disease.
Some research has also evaluated the antioxidant nature of pomegranate juice and its usefulness in fighting certain forms of cancer. Pomegranate juice has been tentatively shown to reduce incidence of breast and skin cancer. It has also been tested and shown to slow the growth of prostate cancer in mice.
Another interesting study has evaluated pomegranate juice and osteoarthritis. Pomegranate juice tends to act as an inhibitor on enzymes responsible for damaging cartilage. These studies applied extract of pomegranate directly onto damaged cartilage. More research would have to examine a cause and effect relationship between oral ingestion of pomegranate juice and reduction in cartilage deterioration.
Further, pomegranate juice has excellent antioxidant properties. It has about three times more antioxidants ounce for ounce than does red wine or green tea. Many people also enjoy its rich taste, making it a welcome beverage.
Pomegranate juice has been shown to work well as a blood thinner. Some research has shown it may be an excellent agent for promoting blood flow to the heart. It also has been shown to reduce plaque in the arteries, and to raise “good” levels of cholesterol while helping lower “bad” cholesterol.
This preliminary research suggests that pomegranate juice may be helpful in preventing heart disease, heart attacks and stroke. Most physicians are quick to point out pomegranate juice should be just one aspect of a healthy diet and exercise program. Pomegranate juice alone would probably not cure or completely prevent heart disease.
Some research has also evaluated the antioxidant nature of pomegranate juice and its usefulness in fighting certain forms of cancer. Pomegranate juice has been tentatively shown to reduce incidence of breast and skin cancer. It has also been tested and shown to slow the growth of prostate cancer in mice.
Another interesting study has evaluated pomegranate juice and osteoarthritis. Pomegranate juice tends to act as an inhibitor on enzymes responsible for damaging cartilage. These studies applied extract of pomegranate directly onto damaged cartilage. More research would have to examine a cause and effect relationship between oral ingestion of pomegranate juice and reduction in cartilage deterioration.
Goji Health Stories!
A Very Special Story
I was diagnosed with multiple myeloma (cancer of the bone) and kidney disease (my kidneys were working at 27%) and rheumatoid arthritis. I was severely anemic. I’ve had two knee replacements, an ankle replacement and brain tumor surgery. I suffered with severe pain for many years. I was so sick I said good bye to a lot of my friends and would not leave my house. I couldn’t even go to church.
In May 2004, I was introduced to Goji juice. I took the Goji juice but not as faithfully as I should have which resulted in a slow recovery for me.
I was also on a prescription drug treatment. My doctor increased my dosage 300% because it wasn’t working. In November 2004, my doctor told me to stop taking the drugs and rest my body because my next treatment would be chemotherapy. When I heard that word “chemo”, it really scared me. I started to pray and ask God for strength. That's when I got serious about the Goji juice.
I started drinking 4 to 6 ounces faithfully everyday beginning in November. I began to feel changes in my body. I really couldn't see it but I could feel it.
Then my break through came on March 18, 2005, when I had a lab test. Several days later I had an appointment with my oncologist. I will always remember the expression on his face and the first words that came out from his mouth, "What's up with this"? I believe he was in “shock and awe“. He could not understand what had happened. The doctor told me that my blood count was back to normal and that my kidney function was normal, too. In addition, my arthritis pain was gone.
I praise God for Goji juice, which has changed my life.
Aloha,
Linda D., Hawaii
Acid Reflux/Stomach/Digestion
The day before I found out about Goji juice I prayed that God would help us both financially and with our health. The very next day a gentleman came into the restaurant where I work and shared with me the juice and how it had helped so many people. I was having trouble with stiffness in my hands, acid reflux, and my knees hurt. My husband has had stomach problems for years, achy joints, back problems and after a full day of hard work it took him a long time to snap back.
We started drinking the Goji juice in June 2006 and we loved the taste! Within the first week, husband began to feel energy and began feeling better. I started feeling much better by the end of the second week. My husband no longer has stomach problems, no achy joints and no back pain. I no longer have stiffness in my hands, my knees are much better and do not hurt. I also have not had any acid reflux and we both have more energy. We thank God for sending us the Goji juice!
Sharon H., Ohio
Waiting to Die
One year ago I was discharged from 10 days in the hospital unable to stand, eat, function in any way. I was sent home to die. My daughter, Donna, started me on one ounce of Goji juice three times a day, 1/2 hour before I tried to eat. The Goji juice took effect and within hours I was eating, and within days I was able to walk and function fully. I am pleased to say I am alive and well and happy today thanks to Goji juice. I am 85 years young!
Mable, Washington
A New Life
I will turn 65 in a few months and I do not feel or look my age. I started drinking Goji juice last October and within 2 months I noticed so many changes. Now I have more energy than ever and enough stamina to get me through the day. I sleep through the whole night and when I wake up, I am fully awake. To date, I have lost 42 pounds! I walk and carry my golf clubs when I play golf and I actively kayak and walk for exercise. Goji juice is, without a doubt, the true answer to a long and prosperous life.
Ron W., New York
I was diagnosed with multiple myeloma (cancer of the bone) and kidney disease (my kidneys were working at 27%) and rheumatoid arthritis. I was severely anemic. I’ve had two knee replacements, an ankle replacement and brain tumor surgery. I suffered with severe pain for many years. I was so sick I said good bye to a lot of my friends and would not leave my house. I couldn’t even go to church.
In May 2004, I was introduced to Goji juice. I took the Goji juice but not as faithfully as I should have which resulted in a slow recovery for me.
I was also on a prescription drug treatment. My doctor increased my dosage 300% because it wasn’t working. In November 2004, my doctor told me to stop taking the drugs and rest my body because my next treatment would be chemotherapy. When I heard that word “chemo”, it really scared me. I started to pray and ask God for strength. That's when I got serious about the Goji juice.
I started drinking 4 to 6 ounces faithfully everyday beginning in November. I began to feel changes in my body. I really couldn't see it but I could feel it.
Then my break through came on March 18, 2005, when I had a lab test. Several days later I had an appointment with my oncologist. I will always remember the expression on his face and the first words that came out from his mouth, "What's up with this"? I believe he was in “shock and awe“. He could not understand what had happened. The doctor told me that my blood count was back to normal and that my kidney function was normal, too. In addition, my arthritis pain was gone.
I praise God for Goji juice, which has changed my life.
Aloha,
Linda D., Hawaii
Acid Reflux/Stomach/Digestion
The day before I found out about Goji juice I prayed that God would help us both financially and with our health. The very next day a gentleman came into the restaurant where I work and shared with me the juice and how it had helped so many people. I was having trouble with stiffness in my hands, acid reflux, and my knees hurt. My husband has had stomach problems for years, achy joints, back problems and after a full day of hard work it took him a long time to snap back.
We started drinking the Goji juice in June 2006 and we loved the taste! Within the first week, husband began to feel energy and began feeling better. I started feeling much better by the end of the second week. My husband no longer has stomach problems, no achy joints and no back pain. I no longer have stiffness in my hands, my knees are much better and do not hurt. I also have not had any acid reflux and we both have more energy. We thank God for sending us the Goji juice!
Sharon H., Ohio
Waiting to Die
One year ago I was discharged from 10 days in the hospital unable to stand, eat, function in any way. I was sent home to die. My daughter, Donna, started me on one ounce of Goji juice three times a day, 1/2 hour before I tried to eat. The Goji juice took effect and within hours I was eating, and within days I was able to walk and function fully. I am pleased to say I am alive and well and happy today thanks to Goji juice. I am 85 years young!
Mable, Washington
A New Life
I will turn 65 in a few months and I do not feel or look my age. I started drinking Goji juice last October and within 2 months I noticed so many changes. Now I have more energy than ever and enough stamina to get me through the day. I sleep through the whole night and when I wake up, I am fully awake. To date, I have lost 42 pounds! I walk and carry my golf clubs when I play golf and I actively kayak and walk for exercise. Goji juice is, without a doubt, the true answer to a long and prosperous life.
Ron W., New York
How Does Mangosteen Help with Arthritis?
Is it a Better Alternative than Conventional Drugs?
Arthritis is a disorder characterized by painful and swollen joints. There are over 100 different forms of arthtritis and each is differentiated from the rest by observation of clinical signs and symptoms. The three most common are osteoarthritis, rheumatoid arthritis and gouty arthritis.
Osteoarthritis is the most common form of arthritis and is considered as a degenerative joint disease. It is the result of trauma or infection of the joint, whereas rheumatoid arthritis is a chronic, systemic inflammatory disorder that primarily attacks the joints resulting into synovitis that often leads to the destruction of the articular cartilage. Gouty Arthritis, on the other hand, is characterized by the accumulation of uric acid crystals in the joint, causing inflammation.
In case you’ve been diagnosed with arthritis, you must sit down with your doctor to discuss the best treatment regimen for you. There are plenty of drugs available to treat the disorder but there are drugs that work best for a specific type of arthritis. Patient response to these drugs also vary so it can take time to determine the kind of treatment that would work best for you.
Understanding The Benefits Of Mangosteen And Arthritis Drugs
The most commonly prescribed medication for arthritis is a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). They are also among the most common pain relief medications used today.
NSAIDs are highly effective in relieving arthritic pain but they can also have certain side effects. In order for you to better understand the mechanism of action of these drugs, you must have an idea about pain itself.
Pain is basically your body’s alarm which tells you that something is wrong. Simply put, pain is the result of impulses sent from pain receptors called free nerve endings to your brain. For instance, if you have a wound, the damaged cells release compounds called prostaglandins. These chemicals are known to cause not only tissue swelling and pain but they also amplify the nerve impulses coming from the pain receptors. In short, you feel more intense pain.
Pain has two major types: neuropathic and nociceptive. Neuropathic pain is normally the result of injuries to the nervous system, such as the pain associated with shingles or diabetes. On the other hand, nociceptive pain is caused by injury to tissues outside the nervous system, such as the chronic pain of arthritis.
NSAIDs function on the cellular level. They block the effects of enzymes particularly cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) enzymes which catalyze the conversion of arachidonic acid to inflammatory agents such as prostaglandins and prostacyclins. By simply blocking the cyclo-oxygenase enzymes, NSAIDs essentially prevent your body from producing prostaglandins. As a result, you feel less pain and decreased swelling.
Mangosteen Benefits: Xanthones found in mangosteen function like a COX-2 inhibitor without eliciting the development of stomach ulcers.
What Are The Side Effects From Standard NSAIDs
Gastrointestinal Problems: There are five types of prostaglandins in your body. One type of prostaglandin produced by COX-1 enzyme and an analog called Misoprostol helps protect the stomach lining. Regular intake of NSAIDs blocks COX-1 enzymes and thereby negating the protective function of the prostaglandin. Consequently, NSAIDs cause a significant increase in the prevalence of gastrointestinal problems such as diarrhea and indigestion.
Hypertension and Renal Damage: The mechanism of renal damage spurred by NSAIDs is due to changes in renal hemodynamics. NSAIDs have been shown to reduce the blood flow to the kidneys and affect the function of the nephrons. As a result, salt and fluids are retained in your body. The higher the volume of salt and fluids in your bloodstream, the higher your blood pressure. If the problem goes unchecked, it can cause irreversible damage to your kidneys leading to eventual kidney failure, which may later require dialysis.
Mangosteen Benefits: Recent studies have shown that Xanthones have no harmful influence on blood coagulation and increases blood perfusion rate in the kidneys, thereby enhancing renal function while helping in the regulation of salt and fluid balance in the body.
Allergic Reactions: Some people are allergic to NSAIDs and may develop dyspnea when an NSAID is taken. People with asthma are at a higher risk for having severe allergic reaction to NSAIDs. Health experts generally recommend that people with asthma refrain from taking NSAIDs.
Aside from asthma, there are other allergic reactions that have been associated with NSAIDs, they range from mild to life threatening. The common reactions include skin affectations such as swelling and hives. There are also respiratory problems like rhinitis.
Mangosteen Benefits: Over the last three decades, a lot of studies on xanthones have proven its efficacy in treating various types of allergies. This is due to the fact that xanthones block the formation of histamines – substances that trigger the body’s allergic response.
What Is A COX-2 Inhibitor And What Are The Risks Of It?
COX-2 inhibitors are a form of NSAID that directly target COX-2. Selectivity for COX-2 reduces the risk of gastrointestinal problems such as peptic ulceration. COX-2 inhibitors only block the COX-2 enzyme that’s why these drugs don’t affect the prostaglandins that protect the lining of your stomach.
However, just like other drugs there is a drawback. COX-1 and COX-2 work in tandem to accomplish certain biological tasks. COX-1 also helps in the production of a chemical that stimulates blood clotting and vasoconstriction. These effects are being regulated by another chemical called prostacyclin. It exerts an opposite effect to that of COX-1 because it prevents the formation of the platelet plug and is likewise a potent vasodilator. However, prostacyclin is manufactured, in part, with the aid of COX-2 enzymes. Therefore, blocking only COX-2 means that the effects of blood clotting go unchecked. Consequently, it increases the risk of myocardial infarction and strokes. This is precisely the reason why COX-2 inhibitors have been recalled from the market.
Mangosteen As Treatment For Arthritis
Mangosteen contains antioxidants and remains to be the only thing in nature to embody a broad spectrum of a new type of phytonutrients called xanthones. The two most valuable xanthones found in the mangosteen have been called alpha and gamma mangosteen.
To date, more than 40 different classes of xanthones have been identified in mangosteen. Xanthones are powerful, life-enhancing compounds. In fact, xanthones are by far the most potent antioxidant known to man. It has been claimed to be more powerful than both Vitamins C and E. Additionally, the most dynamic and biologically active type of xanthone is found in mangosteen.
Xanthones are naturally occurring compounds that have recently caught the attention of health and fitness experts and have earned high regard from researchers and scientists alike. Xanthones have been thoroughly studied for their medicinal and pharmaceutical properties.
Based on the results of research studies, the xanthones found in mangosteen can suppress both acute and chronic inflammation, and function like a COX-2 inhibitor without triggering any harmful side effects. Another research conducted to determine mangosteen’s effect on the inflammatory process found out that xanthones have no deleterious influence on blood coagulation and they don’t stimulate the development of stomach ulcers.
Furthermore, testimonies from a number of patients suffering from chronic arthritis claimed that the patients were able to stop or reduce their prescription drugs. The benefits they reaped from mangosteen became evident in as little as a couple of days to beyond three months.
Mangosteen and Arthritis Precaution: So far, mangosteen may not provide the elusive cure to arthritis but it offers that extra ounce of energy required to counter the effects of the disease, effectively alleviates arthritic pain and helps you manage the side effects caused by medications. However, it is worth noting that you may need some time to determine if mangosteen works for you. Likewise, if you are taking any medications, it is recommended to consult your physician regarding any possible drug interaction.
Finally, taking regular mangosteen supplements offer three major health benefits:
Anti-Inflammatory Properties: The benefits derived from mangosteen largely come from its potent anti-inflammatory effects since it effectively blocks the cyclo-oxygenase enzymes without causing any gastrointestinal side effects. Mangosteen also helps to reduce the pain and swelling of the affected joints.
The anti-inflammatory properties of mangosteen have been compared to those of Dexamethasone, one of the most powerful anti-inflammatory prescription drugs. However, Dexamethasone is known to have a long list of adverse side effects. Mangosteen has none of the reported side effects caused by Dexamethasone as well as other anti-inflammatory medications.
Antioxidant: Mangosteen contains a truckload of antioxidants. The mechanism behind the development of arthritis is the gradual degeneration of joint structures. It has been theorized that as people age, the body’s ability to recuperate and repair the damage at the cellular level declines. Antioxidants work on the cellular level by effectively eliminating harmful free radicals, thereby enhancing the body’s innate healing process.
Increase in Energy Helps to Fight Arthritis: If you’re suffering from arthritis, your physician most likely referred you to a physical therapist for treatment sessions. One of the best approaches in physical therapy when it comes to the management of arthritis is the inclusion of an exercise program to improve joint dynamics. A significant increase in energy can help you go through your routine exercise program. In most cases, the mere anticipation of pain while beginning an exercise program can be quite daunting. Mangosteen supplements help provide the energy needed and also aids in the management of pain and anxiety.
Arthritis is a disorder characterized by painful and swollen joints. There are over 100 different forms of arthtritis and each is differentiated from the rest by observation of clinical signs and symptoms. The three most common are osteoarthritis, rheumatoid arthritis and gouty arthritis.
Osteoarthritis is the most common form of arthritis and is considered as a degenerative joint disease. It is the result of trauma or infection of the joint, whereas rheumatoid arthritis is a chronic, systemic inflammatory disorder that primarily attacks the joints resulting into synovitis that often leads to the destruction of the articular cartilage. Gouty Arthritis, on the other hand, is characterized by the accumulation of uric acid crystals in the joint, causing inflammation.
In case you’ve been diagnosed with arthritis, you must sit down with your doctor to discuss the best treatment regimen for you. There are plenty of drugs available to treat the disorder but there are drugs that work best for a specific type of arthritis. Patient response to these drugs also vary so it can take time to determine the kind of treatment that would work best for you.
Understanding The Benefits Of Mangosteen And Arthritis Drugs
The most commonly prescribed medication for arthritis is a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). They are also among the most common pain relief medications used today.
NSAIDs are highly effective in relieving arthritic pain but they can also have certain side effects. In order for you to better understand the mechanism of action of these drugs, you must have an idea about pain itself.
Pain is basically your body’s alarm which tells you that something is wrong. Simply put, pain is the result of impulses sent from pain receptors called free nerve endings to your brain. For instance, if you have a wound, the damaged cells release compounds called prostaglandins. These chemicals are known to cause not only tissue swelling and pain but they also amplify the nerve impulses coming from the pain receptors. In short, you feel more intense pain.
Pain has two major types: neuropathic and nociceptive. Neuropathic pain is normally the result of injuries to the nervous system, such as the pain associated with shingles or diabetes. On the other hand, nociceptive pain is caused by injury to tissues outside the nervous system, such as the chronic pain of arthritis.
NSAIDs function on the cellular level. They block the effects of enzymes particularly cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) enzymes which catalyze the conversion of arachidonic acid to inflammatory agents such as prostaglandins and prostacyclins. By simply blocking the cyclo-oxygenase enzymes, NSAIDs essentially prevent your body from producing prostaglandins. As a result, you feel less pain and decreased swelling.
Mangosteen Benefits: Xanthones found in mangosteen function like a COX-2 inhibitor without eliciting the development of stomach ulcers.
What Are The Side Effects From Standard NSAIDs
Gastrointestinal Problems: There are five types of prostaglandins in your body. One type of prostaglandin produced by COX-1 enzyme and an analog called Misoprostol helps protect the stomach lining. Regular intake of NSAIDs blocks COX-1 enzymes and thereby negating the protective function of the prostaglandin. Consequently, NSAIDs cause a significant increase in the prevalence of gastrointestinal problems such as diarrhea and indigestion.
Hypertension and Renal Damage: The mechanism of renal damage spurred by NSAIDs is due to changes in renal hemodynamics. NSAIDs have been shown to reduce the blood flow to the kidneys and affect the function of the nephrons. As a result, salt and fluids are retained in your body. The higher the volume of salt and fluids in your bloodstream, the higher your blood pressure. If the problem goes unchecked, it can cause irreversible damage to your kidneys leading to eventual kidney failure, which may later require dialysis.
Mangosteen Benefits: Recent studies have shown that Xanthones have no harmful influence on blood coagulation and increases blood perfusion rate in the kidneys, thereby enhancing renal function while helping in the regulation of salt and fluid balance in the body.
Allergic Reactions: Some people are allergic to NSAIDs and may develop dyspnea when an NSAID is taken. People with asthma are at a higher risk for having severe allergic reaction to NSAIDs. Health experts generally recommend that people with asthma refrain from taking NSAIDs.
Aside from asthma, there are other allergic reactions that have been associated with NSAIDs, they range from mild to life threatening. The common reactions include skin affectations such as swelling and hives. There are also respiratory problems like rhinitis.
Mangosteen Benefits: Over the last three decades, a lot of studies on xanthones have proven its efficacy in treating various types of allergies. This is due to the fact that xanthones block the formation of histamines – substances that trigger the body’s allergic response.
What Is A COX-2 Inhibitor And What Are The Risks Of It?
COX-2 inhibitors are a form of NSAID that directly target COX-2. Selectivity for COX-2 reduces the risk of gastrointestinal problems such as peptic ulceration. COX-2 inhibitors only block the COX-2 enzyme that’s why these drugs don’t affect the prostaglandins that protect the lining of your stomach.
However, just like other drugs there is a drawback. COX-1 and COX-2 work in tandem to accomplish certain biological tasks. COX-1 also helps in the production of a chemical that stimulates blood clotting and vasoconstriction. These effects are being regulated by another chemical called prostacyclin. It exerts an opposite effect to that of COX-1 because it prevents the formation of the platelet plug and is likewise a potent vasodilator. However, prostacyclin is manufactured, in part, with the aid of COX-2 enzymes. Therefore, blocking only COX-2 means that the effects of blood clotting go unchecked. Consequently, it increases the risk of myocardial infarction and strokes. This is precisely the reason why COX-2 inhibitors have been recalled from the market.
Mangosteen As Treatment For Arthritis
Mangosteen contains antioxidants and remains to be the only thing in nature to embody a broad spectrum of a new type of phytonutrients called xanthones. The two most valuable xanthones found in the mangosteen have been called alpha and gamma mangosteen.
To date, more than 40 different classes of xanthones have been identified in mangosteen. Xanthones are powerful, life-enhancing compounds. In fact, xanthones are by far the most potent antioxidant known to man. It has been claimed to be more powerful than both Vitamins C and E. Additionally, the most dynamic and biologically active type of xanthone is found in mangosteen.
Xanthones are naturally occurring compounds that have recently caught the attention of health and fitness experts and have earned high regard from researchers and scientists alike. Xanthones have been thoroughly studied for their medicinal and pharmaceutical properties.
Based on the results of research studies, the xanthones found in mangosteen can suppress both acute and chronic inflammation, and function like a COX-2 inhibitor without triggering any harmful side effects. Another research conducted to determine mangosteen’s effect on the inflammatory process found out that xanthones have no deleterious influence on blood coagulation and they don’t stimulate the development of stomach ulcers.
Furthermore, testimonies from a number of patients suffering from chronic arthritis claimed that the patients were able to stop or reduce their prescription drugs. The benefits they reaped from mangosteen became evident in as little as a couple of days to beyond three months.
Mangosteen and Arthritis Precaution: So far, mangosteen may not provide the elusive cure to arthritis but it offers that extra ounce of energy required to counter the effects of the disease, effectively alleviates arthritic pain and helps you manage the side effects caused by medications. However, it is worth noting that you may need some time to determine if mangosteen works for you. Likewise, if you are taking any medications, it is recommended to consult your physician regarding any possible drug interaction.
Finally, taking regular mangosteen supplements offer three major health benefits:
Anti-Inflammatory Properties: The benefits derived from mangosteen largely come from its potent anti-inflammatory effects since it effectively blocks the cyclo-oxygenase enzymes without causing any gastrointestinal side effects. Mangosteen also helps to reduce the pain and swelling of the affected joints.
The anti-inflammatory properties of mangosteen have been compared to those of Dexamethasone, one of the most powerful anti-inflammatory prescription drugs. However, Dexamethasone is known to have a long list of adverse side effects. Mangosteen has none of the reported side effects caused by Dexamethasone as well as other anti-inflammatory medications.
Antioxidant: Mangosteen contains a truckload of antioxidants. The mechanism behind the development of arthritis is the gradual degeneration of joint structures. It has been theorized that as people age, the body’s ability to recuperate and repair the damage at the cellular level declines. Antioxidants work on the cellular level by effectively eliminating harmful free radicals, thereby enhancing the body’s innate healing process.
Increase in Energy Helps to Fight Arthritis: If you’re suffering from arthritis, your physician most likely referred you to a physical therapist for treatment sessions. One of the best approaches in physical therapy when it comes to the management of arthritis is the inclusion of an exercise program to improve joint dynamics. A significant increase in energy can help you go through your routine exercise program. In most cases, the mere anticipation of pain while beginning an exercise program can be quite daunting. Mangosteen supplements help provide the energy needed and also aids in the management of pain and anxiety.
Mangosteen Testimonials
I was diagnosed with Stage 3 pancreatic cancer in February 2005. I had a Whipple surgery and the cancer had spread to my lymph nodes. My prognosis for living longer than 60 days was "dismal". I started drinking mangosteen juice after getting home from the hospital, stopped it by physician orders during chemo and radiation, but resumed when I finished my chemo. I have been in remission for over 3 1/2 years. I believe God is the supreme decision maker of who stays and who doesn't, but I believe the mangosteen juice was as important as the surgery and chemo and radiation. I have two other people who I know personally who are in remission from a grave diagnosis of cancer who also began drinking the mangosteen juice.
- anon22447
Mangosteen is not a silver bullet, it is a supplement to help your body function like it should. And there are more than 14,000 scholarly papers written on the mangosteen and the xanthones they contain. They can be accessed on PubMed.com. So there is a lot of scientific proof that the xanthones in the mangosteen fruit are highly beneficial. Do they cure cancer? Probably not and if someone sells it as if it does should be put out of business. But we all know and understand that if we give our bodies what it needs to be healthy, it will heal itself and fight off disease itself. Unfortunately, we don't get the proper nutrition from our diets, so we all need to supplement (according to JAMA 2002).
I have glaucoma which was diagnosed 25 years ago. I am absolutely certain that I would not have been legal to drive by the end of 2006without this amazing product. My optometrist and opthalmologist could confirm that my vision has improved since starting to take the juice. Would they give mangosteen juice the credit - unlikely, but I know that's what made the difference. I started drinking the juice 5 months after my optometrist said a prescription change would not make a difference, as my poor vision was all due to glaucoma damage. At that point, I was using a magnifying glass to read numbers in the phone book, and that was increasingly difficult. I went to the same optometrist 9 months later, after being on the juice for 4 months, and he was able to give me a new prescription, because my vision had greatly improved. For one thing, the optometrist said the astigmatism in my right eye had been corrected. I was no longer using a magnifying glass. Twelve months later, he was able to give me a major change in the prescription for my left eye, because my vision had greatly improved.
There may not be many "clinical trial" to refer to (by the way do you realize that drug clinical trials can be flawed and results manipulated, and that the studies are funded by the drug companies? hmmm), but don't discount the personal testimonials as "bunk". I would rather die than lie, so you can believe me or not. I am sooo glad I decided I would try the juice. Now, I would rather quit eating than stop using my mangosteen juice, because it is what maintains my vision, so that I can continue to work and enjoy quality of life. If you have problems, try it, you might be pleasantly surprised at the difference it makes for you.
- anon22447
Mangosteen is not a silver bullet, it is a supplement to help your body function like it should. And there are more than 14,000 scholarly papers written on the mangosteen and the xanthones they contain. They can be accessed on PubMed.com. So there is a lot of scientific proof that the xanthones in the mangosteen fruit are highly beneficial. Do they cure cancer? Probably not and if someone sells it as if it does should be put out of business. But we all know and understand that if we give our bodies what it needs to be healthy, it will heal itself and fight off disease itself. Unfortunately, we don't get the proper nutrition from our diets, so we all need to supplement (according to JAMA 2002).
I have glaucoma which was diagnosed 25 years ago. I am absolutely certain that I would not have been legal to drive by the end of 2006without this amazing product. My optometrist and opthalmologist could confirm that my vision has improved since starting to take the juice. Would they give mangosteen juice the credit - unlikely, but I know that's what made the difference. I started drinking the juice 5 months after my optometrist said a prescription change would not make a difference, as my poor vision was all due to glaucoma damage. At that point, I was using a magnifying glass to read numbers in the phone book, and that was increasingly difficult. I went to the same optometrist 9 months later, after being on the juice for 4 months, and he was able to give me a new prescription, because my vision had greatly improved. For one thing, the optometrist said the astigmatism in my right eye had been corrected. I was no longer using a magnifying glass. Twelve months later, he was able to give me a major change in the prescription for my left eye, because my vision had greatly improved.
There may not be many "clinical trial" to refer to (by the way do you realize that drug clinical trials can be flawed and results manipulated, and that the studies are funded by the drug companies? hmmm), but don't discount the personal testimonials as "bunk". I would rather die than lie, so you can believe me or not. I am sooo glad I decided I would try the juice. Now, I would rather quit eating than stop using my mangosteen juice, because it is what maintains my vision, so that I can continue to work and enjoy quality of life. If you have problems, try it, you might be pleasantly surprised at the difference it makes for you.
Saturday, December 12, 2009
COX-1 and COX-2 Inhibitors
What are COX2 (COX-2) Inhibitors and How to They Work?
To understand COX-2 (COX2) Inhibitors, you first have to understand COX-1 (COX1) and what its role in the body is. Regular NSAIDS (Nonsteroidial Anti-inflammatory Drugs) (generally COX-1 and COX-2 Inhibitors) work by inhibiting the production of prostaglandins (PGs). Prostaglandins are fatty-acid derivatives located all over your body that are well known for their inflammation and immune response effects. However, they also have many different roles in the body. A scientific list would read as such: PG’s are involved in as diverse normal processes as ovulation, blood clotting, renal function, wound healing, vasomotor tone, platelet aggregation, differentiation of immune cells, nerve growth, bone metabolism, and initiation of labor. Pretty essential to your body, wouldn’t you say?
If you are familiar with the fact that when you are using drugs such as aspirin, your blood thins and you bruise easier, that is a “side effect” of the COX-1 inhibitor. In the above list, that would fall under the blood clotting category. Remember, COX-1 inhibitors work by inhibiting PG’s. Due to the acidity of the stomach, the cells of your stomach are replaced very quickly, within a few days. One of the major roles of PG’s is to keep the lining of the stomach intact, and when your PG system is disrupted (say by taking COX-1 drugs like many NSAIDS) stomach irritation, digestive tract problems and even intestinal or stomach bleeding and death could occur.
COX-2 inhibitors were discovered later, as a “healthier, more targeted” way of treating the inflammation – without the side effects. This makes sense as COX-2 is found more commonly in inflammatory and immune cells than COX-1 drugs, which exist throughout the body. Unfortunately, this would prove to be far, far from the truth. While COX-2 is more specific to inflammation, the side effects can be worse than COX-1 drugs.
NSAID Side Effects
The side effects of COX-1 drugs are pretty terrible. It is estimated that 25% experience some kind of side effect and 5% develop SERIOUS health consequences such as GI (stomach) bleeding, acute renal failure, or worse. The New England Journal of Medicine reports that “anti-inflammatory drugs (prescription and over-the-counter, which include Advil®, Motrin®, Aleve®, Ordus®, Aspirin, and over 20 others) alone cause over 16,500 deaths and over 103,000 hospitalizations per year in the US”, according to a review article published in the New England Journal of Medicine (1).
You can see why researchers would believe there was a clear cut and dry line between COX-1 and COX-2. The message was clear: research (and get patents for) drugs that actually inhibited only COX-2 and you would have a blockbuster drug on your hands. Unfortunately, like many things, it was not nearly as cut and dry as this. Over the counter drugs such as Ibuprofen and Naproxen work to inhibit COX-1 and COX-2. Aspirin works more on COX-1. Some others such as diclofenac work primarily on COX-2 but also affect COX-1. However, even “selective” COX-2 inhibitors aren’t that selective. At therapeutic dosages, they inhibit enough COX-1 to potentially cause the same stomach toxicity and other associated problems as COX-1. Not to the exact same extent but more than enough to do damage. Remember, 16,500 people are KILLED by “harmless” and “common” NSAIDS such as aspirin or ibuprofen every year.
In development are other “newer aspirins” that may prove to ACTUALLY be more selective for COX-2 than COX-1, but in the mean time – despite claims of being “selective” – the current COX-2’s such as Vioxx® (rofecoxib) or (celecoxib) are simply not selective enough, not to mention some of their potentially horrible side effects and the associated lawsuits that have been filed due to side effects such as heart attacks, stroke and blood clots (2).
Our advice is to explore (for osteoarthritis) other alternative, cheaper and far more effective treatments for your pain. Glucosamine is a natural (and as such not patentable by large drug companies) substance that has been shown to not just be at least as effective as Ibuprofen and other related drugs but also can slow or maybe even stop the spread of osteoarthritis. Plus, it works to rejuvenate cartilage and rebuild the damage that has already occurred. Not even a pure "second generation" COX-2 drug will be able to do that.
To understand COX-2 (COX2) Inhibitors, you first have to understand COX-1 (COX1) and what its role in the body is. Regular NSAIDS (Nonsteroidial Anti-inflammatory Drugs) (generally COX-1 and COX-2 Inhibitors) work by inhibiting the production of prostaglandins (PGs). Prostaglandins are fatty-acid derivatives located all over your body that are well known for their inflammation and immune response effects. However, they also have many different roles in the body. A scientific list would read as such: PG’s are involved in as diverse normal processes as ovulation, blood clotting, renal function, wound healing, vasomotor tone, platelet aggregation, differentiation of immune cells, nerve growth, bone metabolism, and initiation of labor. Pretty essential to your body, wouldn’t you say?
If you are familiar with the fact that when you are using drugs such as aspirin, your blood thins and you bruise easier, that is a “side effect” of the COX-1 inhibitor. In the above list, that would fall under the blood clotting category. Remember, COX-1 inhibitors work by inhibiting PG’s. Due to the acidity of the stomach, the cells of your stomach are replaced very quickly, within a few days. One of the major roles of PG’s is to keep the lining of the stomach intact, and when your PG system is disrupted (say by taking COX-1 drugs like many NSAIDS) stomach irritation, digestive tract problems and even intestinal or stomach bleeding and death could occur.
COX-2 inhibitors were discovered later, as a “healthier, more targeted” way of treating the inflammation – without the side effects. This makes sense as COX-2 is found more commonly in inflammatory and immune cells than COX-1 drugs, which exist throughout the body. Unfortunately, this would prove to be far, far from the truth. While COX-2 is more specific to inflammation, the side effects can be worse than COX-1 drugs.
NSAID Side Effects
The side effects of COX-1 drugs are pretty terrible. It is estimated that 25% experience some kind of side effect and 5% develop SERIOUS health consequences such as GI (stomach) bleeding, acute renal failure, or worse. The New England Journal of Medicine reports that “anti-inflammatory drugs (prescription and over-the-counter, which include Advil®, Motrin®, Aleve®, Ordus®, Aspirin, and over 20 others) alone cause over 16,500 deaths and over 103,000 hospitalizations per year in the US”, according to a review article published in the New England Journal of Medicine (1).
You can see why researchers would believe there was a clear cut and dry line between COX-1 and COX-2. The message was clear: research (and get patents for) drugs that actually inhibited only COX-2 and you would have a blockbuster drug on your hands. Unfortunately, like many things, it was not nearly as cut and dry as this. Over the counter drugs such as Ibuprofen and Naproxen work to inhibit COX-1 and COX-2. Aspirin works more on COX-1. Some others such as diclofenac work primarily on COX-2 but also affect COX-1. However, even “selective” COX-2 inhibitors aren’t that selective. At therapeutic dosages, they inhibit enough COX-1 to potentially cause the same stomach toxicity and other associated problems as COX-1. Not to the exact same extent but more than enough to do damage. Remember, 16,500 people are KILLED by “harmless” and “common” NSAIDS such as aspirin or ibuprofen every year.
In development are other “newer aspirins” that may prove to ACTUALLY be more selective for COX-2 than COX-1, but in the mean time – despite claims of being “selective” – the current COX-2’s such as Vioxx® (rofecoxib) or (celecoxib) are simply not selective enough, not to mention some of their potentially horrible side effects and the associated lawsuits that have been filed due to side effects such as heart attacks, stroke and blood clots (2).
Our advice is to explore (for osteoarthritis) other alternative, cheaper and far more effective treatments for your pain. Glucosamine is a natural (and as such not patentable by large drug companies) substance that has been shown to not just be at least as effective as Ibuprofen and other related drugs but also can slow or maybe even stop the spread of osteoarthritis. Plus, it works to rejuvenate cartilage and rebuild the damage that has already occurred. Not even a pure "second generation" COX-2 drug will be able to do that.
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